GASROS

The GASROS study aims to discover genetic factors that contribute to stroke risk and outcome. Genetic variance in a population can be examined by looking at genetic polymorphisms. By collecting medical history and blood samples from AIS and TIA patients, this study examines the genetic polymorphisms in those who present with cerebrovascular disease and specific stroke-associated phenotypic traits. By additionally collecting follow up information at 3 and 6 months after stroke, this data can be assessed and analyzed to compare patient’s genetic markers with their outcome after stroke. With the aim to develop early preventative measures to treat and reduce or prevent stroke, this study strives to identify specific genetic clues as targets for developing new treatments and provide personalized medicine.


Publications

Integrity of normal-appearing white matter and functional outcomes after acute ischemic stroke.
Etherton MR, Wu O, Cougo P, Giese AK, Cloonan L, Fitzpatrick KM, Kanakis AS, Boulouis G, Karadeli HH, Lauer A, Rosand J, Furie KL, Rost NS.
Neurology. 2017 May 2;88(18):1701-1708. doi: 10.1212/WNL.0000000000003890. Epub 2017 Apr 5.

Genetic Risk Prediction of Atrial Fibrillation.
Lubitz SA, Yin X, Lin HJ, Kolek M, Smith JG, Trompet S, Rienstra M, Rost NS, Teixeira PL, Almgren P, Anderson CD, Chen LY, Engström G, Ford I, Furie KL, Guo X, Larson MG, Lunetta KL, Macfarlane PW, Psaty BM, Soliman EZ, Sotoodehnia N, Stott DJ, Taylor KD, Weng LC, Yao J, Geelhoed B, Verweij N, Siland JE, Kathiresan S, Roselli C, Roden DM, van der Harst P, Darbar D, Jukema JW, Melander O, Rosand J, Rotter JI, Heckbert SR, Ellinor PT, Alonso A, Benjamin EJ; AFGen Consortium.
Circulation. 2017 Apr 4;135(14):1311-1320. doi: 10.1161/CIRCULATIONAHA.116.024143. Epub 2016 Oct 28.

Antecedent Aspirin Use Is Associated with Less Severe Symptoms on Admission for Ischemic Stroke.
Nelson S, Cloonan L, Kanakis AS, Fitzpatrick KM, Shideler KI, Perilla AS, Furie KL, Rost NS.
J Stroke Cerebrovasc Dis. 2016 Oct;25(10):2519-25. doi: 10.1016/j.jstrokecerebrovasdis.2016.06.032. Epub 2016 Jul 18.

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
NINDS Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC).
Lancet Neurol. 2016 Feb;15(2):174-184. doi: 10.1016/S1474-4422(15)00338-5. Epub 2015 Dec 19.

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Barrick TR, Moynihan B, Lewis CM, Boncoraglio GB, Lemmens R, Thijs V, Sudlow C, Wardlaw J, Rothwell PM, Meschia JF, Worrall BB, Levi C, Bevan S, Furie KL, Dichgans M, Rosand J, Markus HS, Rost N; International Stroke Genetics Consortium.
Neurology. 2016 Jan 12;86(2):146-53. doi: 10.1212/WNL.0000000000002263. Epub 2015 Dec 16.

Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury.
Du R, Zhou J, Lorenzano S, Liu W, Charoenvimolphan N, Qian B, Xu J, Wang J, Zhang X, Wang X, Berndt A, Devan WJ, Valant VJ, Wang J, Furie KL, Rosand J, Rost N, Friedlander RM, Paigen B, Weiss ST.
Stroke. 2015 Dec;46(12):3514-22. doi: 10.1161/STROKEAHA.115.010767. Epub 2015 Nov 5.

Role of Acute Lesion Topography in Initial Ischemic Stroke Severity and Long-Term Functional Outcomes.
Wu O, Cloonan L, Mocking SJ, Bouts MJ, Copen WA, Cougo-Pinto PT, Fitzpatrick K, Kanakis A, Schaefer PW, Rosand J, Furie KL, Rost NS.
Stroke. 2015 Sep;46(9):2438-44. doi: 10.1161/STROKEAHA.115.009643. Epub 2015 Jul 21.

COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease.
Oliveira-Filho J, Ornellas AC, Zhang CR, Oliveira LM, Araújo-Santos T, Borges VM, Ventura LM, Reis FJ, Aras R, Fernandes AM, Rosand J, Greenberg SM, Furie KL, Rost NS.
J Stroke Cerebrovasc Dis. 2015 Aug;24(8):1817-22. doi:10.1016/j.jstrokecerebrovasdis.2015.04.018. Epub 2015 May 6.

Metabolic determinants of white matter hyperintensity burden in patients with ischemic stroke.
Cloonan L, Fitzpatrick KM, Kanakis AS, Furie KL, Rosand J, Rost NS.
Atherosclerosis. 2015 May;240(1):149-53. doi: 10.1016/j.atherosclerosis.2015.02.052. Epub 2015 Mar 2.

B-type natriuretic peptides help in cardioembolic stroke diagnosis: pooled data meta-analysis.
Llombart V, Antolin-Fontes A, Bustamante A, Giralt D, Rost NS, Furie K, Shibazaki K, Biteker M, Castillo J, Rodríguez-Yáñez M, Fonseca AC, Watanabe T, Purroy F, Zhixin W, Etgen T, Hosomi N, Jafarian Kerman SR, Sharma JC, Knauer C, Santamarina E, Giannakoulas G, García-Berrocoso T, Montaner J.
Stroke. 2015 May;46(5):1187-95. doi: 10.1161/STROKEAHA.114.008311. Epub 2015 Mar 12. Review.

Determinants of white matter hyperintensity burden differ at the extremes of ages of ischemic stroke onset.
Zhang CR, Cloonan L, Fitzpatrick KM, Kanakis AS, Ayres AM, Furie KL, Rosand J, Rost NS.
J Stroke Cerebrovasc Dis. 2015 Mar;24(3):649-54. doi: 10.1016/j.jstrokecerebrovasdis.2014.10.016. Epub 2014 Nov 6.

Segmentation of cerebrovascular pathologies in stroke patients with spatial and shape priors.
Dalca AV, Sridharan R, Cloonan L, Fitzpatrick KM, Kanakis A, Furie KL, Rosand J, Wu O, Sabuncu M, Rost NS, Golland P.
MICCAI. 2014;17(Pt 2):773-80.

White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke.
Corbin ZA, Rost NS, Lorenzano S, Kernan WN, Parides MK, Blumberg JB, Milbury PE, Arai K, Hartdegen SN, Lo EH, Feske SK, Furie KL.
J Stroke Cerebrovasc Dis. 2014 Jul;23(6):1300-6. doi: 10.1016/j.jstrokecerebrovasdis.2013.11.002. Epub 2014 Jan 16.

17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status.
Adib-Samii P, Rost N, Traylor M, Devan W, Biffi A, Lanfranconi S, Fitzpatrick K, Bevan S, Kanakis A, Valant V, Gschwendtner A, Malik R, Richie A, Gamble D, Segal H, Parati EA, Ciusani E, Holliday EG, Maguire J, Wardlaw J, Worrall B, Bis J, Wiggins KL, Longstreth W, Kittner SJ, Cheng YC, Mosley T, Falcone GJ, Furie KL, Leiva-Salinas C, Lau BC, Saleem Khan M; Australian Stroke Genetics Collaborative; Wellcome Trust Case-Control Consortium-2 (WTCCC2); METASTROKE, Sharma P, Fornage M, Mitchell BD, Psaty BM, Sudlow C, Levi C, Boncoraglio GB, Rothwell PM, Meschia J, Dichgans M, Rosand J, Markus HS; International Stroke Genetics Consortium.
Stroke. 2013 Jun;44(6):1609-15. doi: 10.1161/STROKEAHA.113.679936. Epub 2013 May 14.

Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhage.
Anderson CD, Biffi A, Nalls MA, Devan WJ, Schwab K, Ayres AM, Valant V, Ross OA, Rost NS, Saxena R, Viswanathan A, Worrall BB, Brott TG, Goldstein JN, Brown D, Broderick JP, Norrving B, Greenberg SM, Silliman SL, Hansen BM, Tirschwell DL, Lindgren A, Slowik A, Schmidt R, Selim M, Roquer J, Montaner J, Singleton AB, Kidwell CS, Woo D, Furie KL, Meschia JF, Rosand J; International Stroke Genetics Consortium.
Stroke. 2013 Mar;44(3):612-9. doi: 10.1161/STROKEAHA.112.672089. Epub 2013 Jan 29.

Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials.
Ní Chróinín D, Asplund K, Åsberg S, Callaly E, Cuadrado-Godia E, Díez-Tejedor E, Di Napoli M, Engelter ST, Furie KL, Giannopoulos S, Gotto AM Jr, Hannon N, Jonsson F, Kapral MK, Martí-Fàbregas J, Martínez-Sánchez P, Milionis HJ, Montaner J, Muscari A, Pikija S, Probstfield J, Rost NS, Thrift AG, Vemmos K, Kelly PJ.
Stroke. 2013 Feb;44(2):448-56. doi: 10.1161/STROKEAHA.112.668277. Epub 2013 Jan 3. Review.

Quantification and Analysis of Large Multimodal Clinical Image Studies: Application to Stroke.
Sridharan R, Dalca AV, Fitzpatrick KM, Cloonan L, Kanakis A, Wu O, Furie KL, Rosand J, Rost NS, Golland P.
Multimodal Brain Image Anal (2013). 2013;8159:18-30. doi: 10.1007/978-3-319-02126-3_3.

Severity of leukoaraiosis in large vessel atherosclerotic disease.
Chutinet A, Biffi A, Kanakis A, Fitzpatrick KM, Furie KL, Rost NS.
AJNR Am J Neuroradiol. 2012 Sep;33(8):1591-5. doi: 10.3174/ajnr.A3015. Epub 2012 Mar 15.

Genome-wide association analysis of ischemic stroke in young adults.
Cheng YC, O'Connell JR, Cole JW, Stine OC, Dueker N, McArdle PF, Sparks MJ, Shen J, Laurie CC, Nelson S, Doheny KF, Ling H, Pugh EW, Brott TG, Brown RD Jr, Meschia JF, Nalls M, Rich SS, Worrall B, Anderson CD, Biffi A, Cortellini L, Furie KL, Rost NS, Rosand J, Manolio TA, Kittner SJ, Mitchell BD.
G3 (Bethesda). 2011 Nov;1(6):505-14. doi: 10.1534/g3.111.001164. Epub 2011 Nov 1.

Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?
Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD Jr, Chen F, Chen WM, Ciusani E, Cole JW, Cortellini L, Danesh J, Doheny K, Ferrucci L, Grazia Franzosi M, Frossard P, Furie KL, Golledge J, Hankey GJ, Hernandez D, Holliday EG, Hsu FC, Jannes J, Kamal A, Khan MS, Kittner SJ, Koblar SA, Lewis M, Lincz L, Lisa A, Matarin M, Moscato P, Mychaleckyj JC, Parati EA, Parolo S, Pugh E, Rost NS, Schallert M, Schmidt H, Scott RJ, Sturm JW, Yadav S, Zaidi M, Boncoraglio GB, Levi CR, Meschia JF, Rosand J, Sale M, Saleheen D, Schmidt R, Sharma P, Worrall B, Mitchell BD; GARNET Collaborative Research Group; GENEVA Consortium; International Stroke Genetics Consortium.
Stroke. 2012 Apr;43(4):980-6. doi: 10.1161/STROKEAHA.111.632075. Epub 2012 Feb 23.
Erratum in:Stroke. 2015 Aug;46(8):e204.

Brain natriuretic peptide predicts functional outcome in ischemic stroke.
Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL.
Stroke. 2012 Feb;43(2):441-5. doi: 10.1161/STROKEAHA.111.629212. Epub 2011 Nov 23.

Severity of leukoaraiosis determines clinical phenotype after brain infarction.
Arsava EM, Bayrlee A, Vangel M, Rost NS, Rosand J, Furie KL, Sorensen AG, Ay H.
Neurology. 2011 Jul 5;77(1):55-61. doi: 10.1212/WNL.0b013e318221ad02. Epub 2011 Jun 22.

Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis.
Biffi A, Devan WJ, Anderson CD, Cortellini L, Furie KL, Rosand J, Rost NS.
Stroke. 2011 May;42(5):1314-9. doi: 10.1161/STROKEAHA.110.605923. Epub 2011 Mar 17. Review.

White matter hyperintensity volume is increased in small vessel stroke subtypes.
Rost NS, Rahman RM, Biffi A, Smith EE, Kanakis A, Fitzpatrick K, Lima F, Worrall BB, Meschia JF, Brown RD Jr, Brott TG, Sorensen AG, Greenberg SM, Furie KL, Rosand J.
Neurology. 2010 Nov 9;75(19):1670-7. doi: 10.1212/WNL.0b013e3181fc279a.

White matter hyperintensity burden and susceptibility to cerebral ischemia.
Rost NS, Fitzpatrick K, Biffi A, Kanakis A, Devan W, Anderson CD, Cortellini L, Furie KL, Rosand J.
Stroke. 2010 Dec;41(12):2807-11. doi: 10.1161/STROKEAHA.110.595355. Epub 2010 Oct 14.

Common mitochondrial sequence variants in ischemic stroke.
Anderson CD, Biffi A, Rahman R, Ross OA, Jagiella JM, Kissela B, Cole JW, Cortellini L, Rost NS, Cheng YC, Greenberg SM, de Bakker PI, Brown RD Jr, Brott TG, Mitchell BD, Broderick JP, Worrall BB, Furie KL, Kittner SJ, Woo D, Slowik A, Meschia JF, Saxena R, Rosand J; International Stroke Genetics Consortium.
Ann Neurol. 2011 Mar;69(3):471-80. doi: 10.1002/ana.22108. Epub 2010 Sep 13.

Principal-component analysis for assessment of population stratification in mitochondrial medical genetics.
Biffi A, Anderson CD, Nalls MA, Rahman R, Sonni A, Cortellini L, Rost NS, Matarin M, Hernandez DG, Plourde A, de Bakker PI, Ross OA, Greenberg SM, Furie KL, Meschia JF, Singleton AB, Saxena R, Rosand J.
Am J Hum Genet. 2010 Jun 11;86(6):904-17. doi: 10.1016/j.ajhg.2010.05.005. Epub 2010 May 27.

Determinants of white matter hyperintensity volume in patients with acute ischemic stroke.
Rost NS, Rahman R, Sonni S, Kanakis A, Butler C, Massasa E, Cloonan L, Gilson A, Delgado P, Chang Y, Biffi A, Jimenez-Conde J, Besanger A, Silva G, Smith EE, Rosand J, Furie KL.
J Stroke Cerebrovasc Dis. 2010 May;19(3):230-5. doi:10.1016/j.jstrokecerebrovasdis.2009.05.007.

Failure to validate association between 12p13 variants and ischemic stroke.
International Stroke Genetics Consortium; Wellcome Trust Case-Control Consortium 2.
N Engl J Med. 2010 Apr 22;362(16):1547-50. doi: 10.1056/NEJMc0910050. No abstract available.

Chromosome 9p21 in ischemic stroke: population structure and meta-analysis.
Anderson CD, Biffi A, Rost NS, Cortellini L, Furie KL, Rosand J.
Stroke. 2010 Jun;41(6):1123-31. doi: 10.1161/STROKEAHA.110.580589. Epub 2010 Apr 15.

Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke.
Jimenez-Conde J, Biffi A, Rahman R, Kanakis A, Butler C, Sonni S, Massasa E, Cloonan L, Gilson A, Capozzo K, Cortellini L, Ois A, Cuadrado-Godia E, Rodriguez-Campello A, Furie KL, Roquer J, Rosand J, Rost NS.
Stroke. 2010 Mar;41(3):437-42. doi: 10.1161/STROKEAHA.109.563502. Epub 2010 Feb 4.
Erratum in: Stroke. 2017 Aug;48(8):e241.

Remote supervision of IV-tPA for acute ischemic stroke by telemedicine or telephone before transfer to a regional stroke center is feasible and safe.
Pervez MA, Silva G, Masrur S, Betensky RA, Furie KL, Hidalgo R, Lima F, Rosenthal ES, Rost N, Viswanathan A, Schwamm LH.
Stroke. 2010 Jan;41(1):e18-24. doi: 10.1161/STROKEAHA.109.560169. Epub 2009 Nov 12.

Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke.
Arsava EM, Rahman R, Rosand J, Lu J, Smith EE, Rost NS, Singhal AB, Lev MH, Furie KL, Koroshetz WJ, Sorensen AG, Ay H.
Neurology. 2009 Apr 21;72(16):1403-10. doi: 10.1212/WNL.0b013e3181a18823.