The MRI-GENIE study specifically investigates the genetic contribution to acute and chronic stroke burden. With our collaborators, we have created a Neuroimaging Repository of MRI scans that, combined with corresponding genetic information, allows us to explore stroke at the genomic level.

Building off of the Stroke Genetic Networks Study (SiGN), MRI-GENIE is the first funded sub-study that has created an automatic pipeline to extract clinically relevant cerebrovascular MRI traits and perform extensive analyses of these traits. By combining neuroimaging data with genetic analyses, MRI-GENIE aims to discover genetic determinants of these stroke-related MRI traits to identify the underlying genetic architecture of stroke risk and outcomes in acute ischemic stroke (AIS).

Automated pipeline

We have developed an automated, volumetric analysis MRI pipeline to analyze the clinical MRIs of acute stroke cases. This allows our team to characterize the amount of acute and chronic vascular brain lesions based on MRI. Designed as a high throughput, multimodal clinical pipeline, it serves as an MRI analysis platform that will advance genetic discovery in stroke and help shape the methodology of stroke analysis in future research.

Genetic Exploration

In parallel, we are looking to discover genetic variants associated with the acute and chronic MRI-based manifestations of cerebrovascular disease. Identifying these genetic variants will provide clinical advances and personalized medicine.

Collaborations

Collaborations spanning 12 sites worldwide have built up MRI-GENIE’s Neuroimaging Repository to 3301 cases for analysis. MRI-GENIE leverages the expertise of NINDS SiGN, ISGC (International Stroke Genetics Consortium) and MIT as collaborators in order to assess the genetic underpinnings of acute and chronic stroke lesions as seen on MRI scans. The study builds upon an ongoing multi-center, NIH-funded collaboration within the community of stroke neurologists, geneticists, and neuroimaging analysts who together provide a broad spectrum of expertise and contributions to this project.


12 Current Sites:
Ischemic Stroke Genetics Study
ISGS
Genetics of Early Onset Stroke
GEOS
SAHLSIS
GOTENBURG
Leuven Study
LEUVEN
Greater Cincinnati Northern Kentucky Stroke Study
GCKNSS
BASICMAR Gene
BASICMAR
Krakow Study
KRAKOW
Genes Associated with Stroke Risk and Outcome Study
GASROS
Bio-Repository of DNA in Stroke
BRAINS
Lund Study
LUND
Miami Stroke Registry
MIAMISR
Graz Study
GRAZ
Incoming Sites:
The Australian Stroke Genetics Collaborative
ASCS
Stroke in Young Fabry Patients
SIFAP
Observational Dutch Young Symptomatic StrokE studY
ODDESSEY
Helsinki 2000 Genetics of Ischemic Stroke
HELSINKI
Secondary Prevention of Small Subcortical Stroke
SPS3
Stroke Center Biospeciman & Genomic Outcome/Recovery
WASHU
The Siblings With Ischemic Stroke Study
SWISS
University of Campinas
UNICAMP
Geisinger Medical Center
GEISINGER